Toxicological effects of silver nanoparticles in rats

被引：65
|
作者：
Sardari, Roshan Rezaee Ranjbar [2 ]
Zarchi, Saeid Rezaei [3 ]
Talebi, Alireza [4 ]
Nasri, Sima [5 ]
Imani, Saber [1 ]
Khoradmehr, Arezoo [6 ]
Sheshde, Seyed Alireza Razavi [7 ]
机构：
[1] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran
[2] Payame Noor Univ, Dept Biol, Yazd, Iran
[3] Payame Noor Univ, Dept Biol, Taft, Iran
[4] Shahid Sadughi Univ Med Sci, Res & Clin Ctr Infertil, Yazd, Iran
[5] Payame Noor Univ, Dept Biol, Tehran, Iran
[6] Yazd Univ, Res & Clin Ctr Infertil, Tehran, Iran
[7] Sari Agr & Nat Resources Univ, Coll Anim Sci & Fisheries, Dept Anim Sci, Sari, Iran
来源：
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2012年 / 6卷 / 27期
关键词：
Silver; nanoparticle; kidney; liver; spleen; toxicity; rat; TOXICITY; CELLS;
D O I：
10.5897/AJMR11.1070
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Toxicity of nanoparticles depends on chemical composition, atomic arrangement and particle size. Silver is being widely used in consumer medical products, due to its uniqueness such as antimicrobial activity. In this study, we assessed the toxic effects of size-silver nanoparticles 70 nanometer in rat's living tissues, with different doses such as 0.25, 0.5, 1 and 2 mg/kg body weight on kidney, liver and spleen tissues via oral gavage for 30 days. Adverse impacts on liver, spleen and kidney were observed in a high dose-treated group (1 and 2 mg/kg), when determined by histopathological analysis. Pathological examination showed tissue damages, bloodshed, cell necrosis and apoptosis from all rat in high dose group compared to control group. Based on these results, it is suggested that the effect of nanosilver particles on the tissues may cause organ toxicity in rats.
引用
收藏
页码：5587 / 5593
页数：7
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