Discovery and functional characterization of small molecule inhibitors of SWI/SNFATPase activity in BRG1/SMARCA4-Deficient non small cell lung cancers

被引:0
|
作者
Jagani, Z. [1 ]
Chenail, G. [1 ]
Xiang, K. [1 ]
Bushold, G. [1 ]
Bhang, C. [1 ]
Li, A. [1 ]
Vattay, A. [1 ]
Gilbert, T. [1 ]
Zhu, J. [2 ]
Terranova, R. [3 ]
Dubost, V. [3 ]
Huet, F. [4 ]
Farley, D. [5 ]
Cantwell, J. [6 ]
Ruddy, D. [1 ]
Rakiec, D. [1 ]
Shirley, M. [1 ]
Elliott, G. [1 ]
Nakajima, K. [7 ]
Papillon, J. [7 ]
机构
[1] Novartis Inst BioMed Res, Oncol, Cambridge, MA USA
[2] Novartis Inst BioMed Res, Sci Data Analyt, Cambridge, MA USA
[3] Novartis Inst BioMed Res, Preclin Safety, Basel, Switzerland
[4] Novartis Inst BioMed Res, PreClin Safety, Cambridge, MA USA
[5] Novartis Inst BioMed Res, Chem Biol & Therapeut, Cambridge, MA USA
[6] Novartis Inst BioMed Res, Prot Sci, Emeryville, CA USA
[7] Novartis Inst BioMed Res, Global Discovery Chem, Cambridge, MA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
19 (PB-199
引用
收藏
页码:E23 / E23
页数:1
相关论文
共 50 条
  • [41] Hyper-progressive disease after immune checkpoint inhibitor in SMARCA4-deficient small-cell lung carcinoma
    Chiba, Yosuke
    Kawanami, Toshinori
    Yamasaki, Kei
    Uchimura, Keigo
    Matsuyama, Atsuji
    Yatera, Kazuhiro
    RESPIROLOGY CASE REPORTS, 2020, 8 (08):
  • [42] SMARCA4-deficient non-small cell lung carcinoma: clinicodemographic, computed tomography, and positron emission tomography-computed tomography features
    Kim, Jong Hee
    Woo, Jung Han
    Lim, Chae Young
    An, Taein
    Han, Joungho
    Chung, Myung Jin
    Cha, Yoon Ki
    JOURNAL OF THORACIC DISEASE, 2024, 16 (03) : 1753 - 1764
  • [43] SMARCA4/BRG1-deficient non-small cell lung cancer: clinical, imaging, pathological features, and follow-up results of 23
    Wumener, Xieraili
    Ye, Xiaoxing
    Zhang, Yarong
    Tuya, E.
    Zhao, Jiuhui
    Liang, Ying
    Zhao, Jun
    TRANSLATIONAL LUNG CANCER RESEARCH, 2025, 14 (01) : 107 - 123
  • [44] Pulmonary BRG1 (SMARCA4)-deficient undifferentiated neoplasms represent an exceptionally aggressive type of sarcomatoid carcinoma: Clinicopathologic and genomic evidence supports a link to non-small cell carcinoma
    Montecalvo, Joseph
    Alex, Deepu
    Ptashkin, Ryan
    Ni, Ai
    Sauter, Jennifer L.
    Chang, Jason
    Jungbluth, Achim
    Beras, Amanda
    Namakydoust, Azadeh
    Rudin, Charles
    Ladanyi, Marc
    Antonescu, Cristina R.
    Travis, William
    Rekhtman, Natasha
    LABORATORY INVESTIGATION, 2018, 98 : 742 - 742
  • [45] Pulmonary BRG1 (SMARCA4)-deficient undifferentiated neoplasms represent an exceptionally aggressive type of sarcomatoid carcinoma: Clinicopathologic and genomic evidence supports a link to non-small cell carcinoma
    Montecalvo, Joseph
    Alex, Deepu
    Ptashkin, Ryan
    Ni, Ai
    Sauter, Jennifer L.
    Chang, Jason
    Jungbluth, Achim
    Beras, Amanda
    Namakydoust, Azadeh
    Rudin, Charles
    Ladanyi, Marc
    Antonescu, Cristina R.
    Travis, William
    Rekhtman, Natasha
    MODERN PATHOLOGY, 2018, 31 : 742 - 742
  • [46] Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer
    Fukuoka, J
    Fujii, T
    Shih, JH
    Dracheva, T
    Meerzaman, D
    Player, A
    Hong, K
    Settnek, S
    Gupta, A
    Buetow, K
    Hewitt, S
    Travis, WD
    Jen, J
    CLINICAL CANCER RESEARCH, 2004, 10 (13) : 4314 - 4324
  • [47] Unravelling switch/sucrose non-fermentable (SWI-SNF) complex-deficient thoracic tumours: a clinicopathological comparative on undifferentiated tumours and non-small cell lung carcinomas with BRG1 and BRM deficiency
    Sood, Ridhi
    Tandon, Arshi
    Khatoon, Warisa
    Vasanthraman, Jayashimman
    Nambirajan, Aruna
    Mohan, Anant
    Malik, Prabhat Singh
    Jain, Deepali
    JOURNAL OF CLINICAL PATHOLOGY, 2024,
  • [48] SMARCA4 deficient non-small cell lung carcinoma: immunohistochemistry and molecular genetic study
    Raskin, G.
    Fedorova, A.
    Mukhina, M.
    Drui, A.
    Chernev, A.
    Zavalishina, L.
    VIRCHOWS ARCHIV, 2024, 485 : S143 - S143
  • [49] BRG1 and p53 Expression in Resected Stage I - III Non-Small Cell Lung Cancer
    Elegbede, A.
    Koebel, M.
    D'Silva, A.
    Dean, M.
    Enwere, E.
    Tudor, R.
    Gibson, A.
    Li, H.
    Otsuka, S.
    Bebb, G.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S2124 - S2124
  • [50] Dynamic and Static 18F-FDG PET/CT Imaging in SMARCA4-Deficient Non-Small Cell Lung Cancer and Response to Therapy: A Case Report
    Wumener, Xieraili
    Ye, Xiaoxing
    Zhang, Yarong
    Jin, Shi
    Liang, Ying
    DIAGNOSTICS, 2023, 13 (12)