Binding properties of oligonucleotides containing a modified 2′-deoxyuridine with a thymine ended linker to pair with 2′-deoxyadenosine

被引：1
|
作者：
Savy, P
Benhida, R
Fourrey, JL [1 ]
Maurisse, R
Sun, JS
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
[2] Museum Natl Hist Nat, Biophys Lab, F-75231 Paris 05, France
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 06期
关键词：
D O I：
10.1016/S0960-894X(02)00062-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Oligonucleotides containing in the place of thymidine the nucleoside 2, a 2'-deoxyuridine harbouring at C-5 a thytnine ended linker, were found to undergo base pairing with the opposite 2'-deoxyadenosine. However, the corresponding duplexes are significantly destabilised as compared to the fully natural ones. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：981 / 983
页数：3
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