RISK OF SCRAPIE FOR ROMANIAN TURCANA SHEEP OF PRION PROTEIN GENOTYPE ARQ/ARQ

The Romanian Turcana sheep it is a national breed with multiple quality: adaptability in rough climate, rusticity but with insufficient production of actual necessity. The research team collected samples from animals in Transylvania area to identify valuable genotypes resistance to scrapie disease. For classical scrapie the codon 171 is thought to be the major determinant of susceptibility, with glutamine (Q) and histidine (H) conferring susceptibility and arginine (R) resistance. The results of county analysis shows evidence 46 alanine (A) at codon 136 that confers resistance to scrapie prion structural changes. The presence of glutamine (Q) or histidine at codon 171 may send some characters of resistance to scrapie that was not detected in these samples. The analytical results from 126 samples the presence of glutamine (Q) in codon 171 of prion structural changes that confer resistance to scrapie prion. It is identify the case of scrapie with clinical signs with genotype ARQ/ARQ considered very low susceptibility to scrapie in Europe.