Daptomycin for the treatment of gram-positive infections after cardiac surgery

被引：0
|
作者：
Luchting, B. [1 ]
Weis, F. [1 ]
Heyn, J. [1 ]
Beiras-Fernandez, A. [2 ,3 ]
机构：
[1] Klinikum Univ Munchen, Klin Anaesthesiol, Munich, Germany
[2] Klinikum Univ Munchen, Herzchirurg Klin & Poliklin, Munich, Germany
[3] Klinikum Johann Wolfgang Goethe Univ, D-60590 Frankfurt, Germany
来源：
MEDIZINISCHE KLINIK-INTENSIVMEDIZIN UND NOTFALLMEDIZIN | 2013年 / 108卷 / 01期
关键词：
Gram-positive Infections; Daptomycin; Cardiac surgery; Resistences; Efficacy; RESISTANT STAPHYLOCOCCUS-AUREUS; MAJOR HEART-SURGERY; POSTOPERATIVE MEDIASTINITIS; CLINICAL-EVIDENCE; JOINT INFECTIONS; VANCOMYCIN; THERAPY; ENDOCARDITIS; BACTEREMIA; PATIENT;
D O I：
10.1007/s00063-012-0163-5
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background and method. Surgical infection remains a main cause of death after heart surgery, despite advances in pharmacological therapy. Daptomycin is a cyclic lipopeptide antibiotic, useful in gram-positive organisms resistant to standard treatment, including vancomycin. The aim of this study was to describe the use of daptomycin regarding efficacy, efficiency and safety in patients with gram-positive infections after heart surgery using a retrospective analysis on 49 adult patients. Conclusion. Daptomycin shows excellent in vitro and in vivo activity against gram-positive organisms, such as Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, especially MRSA. Daptomycin is also effective against increasing vancomycin-resistant or vancomycin-intermediate S. aureus.
引用
收藏
页码：59 / 62
页数：4
相关论文
共 50 条
  • [21] Daptomycin treatment of patients with gram-positive bacteremia
    DeBruin, MF
    Tally, FP
    INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2000, 21 (02): : 95 - 95
  • [22] Daptomycin use in neutropenic patients with documented gram-positive infections
    Kenneth V. I. Rolston
    Dina Besece
    Kenneth C. Lamp
    Min Yoon
    Scott A. McConnell
    Pamela White
    Supportive Care in Cancer, 2014, 22 : 7 - 14
  • [23] Daptomycin use in neutropenic patients with documented gram-positive infections
    Rolston, Kenneth V. I.
    Besece, Dina
    Lamp, Kenneth C.
    Yoon, Min
    McConnell, Scott A.
    White, Pamela
    SUPPORTIVE CARE IN CANCER, 2014, 22 (01) : 7 - 14
  • [24] Daptomycin therapy for gram-positive infections in cancer patients.
    Hogan, HL
    Raad, I
    Rolston, KVI
    JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 776S - 776S
  • [25] Daptomycin therapy for invasive Gram-positive bacterial infections in children
    Ardura, Monica I.
    Mejias, Asuncion
    Katz, Kathy S.
    Revell, Paula
    McCracken, George H., Jr.
    Sanchez, Pablo J.
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2007, 26 (12) : 1128 - 1132
  • [26] Daptomycin: an evidence-based review of its role in the treatment of Gram-positive infections
    Gonzalez-Ruiz, Armando
    Seaton, R. Andrew
    Hamed, Kamal
    INFECTION AND DRUG RESISTANCE, 2016, 9 : 47 - 58
  • [27] Daptomycin is safe and effective for the treatment of gram-positive cocci infections in solid organ transplantation
    Len, O.
    Montejo, M.
    Cervera, C.
    Farinas, M. C.
    Sabe, N.
    Ramos, A.
    Cordero, E.
    Torre-Cisneros, J.
    Martin-Davila, P.
    Azanza, J. R.
    Pahissa, A.
    Gavalda, J.
    TRANSPLANT INFECTIOUS DISEASE, 2014, 16 (04) : 532 - 538
  • [28] Safety and Efficacy of Daptomycin in the Treatment of Gram-Positive Pathogens
    Kelesidis, Theodoros
    CLINICAL MEDICINE INSIGHTS-THERAPEUTICS, 2011, 3 : 403 - 414
  • [29] DEVELOPMENTS IN TREATMENT OF GRAM-POSITIVE INFECTIONS
    WHITBY, M
    CURRENT OPINION IN INFECTIOUS DISEASES, 1989, 2 (03) : 349 - 352
  • [30] Introduction: treatment of Gram-positive infections
    Wise, R
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 : 5 - 7
12345