Synthesis of Optically Pure Macroheterocycle with Ester and Hydrazide Fragments on the Basis of l-Menthol

被引：3

作者：

Ishmuratov, Gumer Yu. ^{[1
]}

Yakovleva, Marina P. ^{[1
]}

Mingaleeva, Galina R. ^{[1
]}

Shutova, Mariya A. ^{[1
]}

Muslukhov, Rinat R. ^{[1
]}

Viripaev, Evgeny M. ^{[1
]}

Tolstikov, Alexander G. ^{[1
]}

机构：

[1] RAS, Ufa Sci Ctr, Inst Organ Chem, Ufa 450054, Russia

来源：

MACROHETEROCYCLES | 2012年 / 5卷 / 03期

关键词：

l-Menthol; O; N-macroheterocycles; ester and hydrazide functions; synthesis;

D O I：

10.6060/mhc2012.120359y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Based on l-menthol we have developed a synthesis method for potentially useful optically pure methyl-and isopropylbranched 21-member macrolide with hydrazide and ester fragments via sequential [2+1]-condensation of methyl-(3R, 6S)-6-hydroxy-3,7-dimethyl octanoate with glutaric acid chloranhydride and [1+1]-reaction of intermediate tetraester with hydrazine hydrate. The evidence is given for the structure of the obtained macrocycle using IR and NMR spectroscopy and mass spectrometry.

引用

页码：246 / 248

页数：3

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