Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik-Fields reaction applying amides as the starting materials

被引：10

作者：

Tripolszky, Anna ^{[1
]}

Zoboki, Lili ^{[1
]}

Balint, Erika ^{[1
]}

Koti, Janos ^{[2
]}

Keglevich, Gyorgy ^{[1
]}

机构：

[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary

[2] Gedeon Richter Plc, Budapest, Hungary

来源：

SYNTHETIC COMMUNICATIONS | 2019年 / 49卷 / 08期

关键词：

alpha-Aminophosphine oxides; carboxylic acid amides; Kabachnik-Fields reaction; microwave; AMINO PHOSPHONATES; SOLVENT-FREE; IONIC LIQUID; EFFICIENT; CATALYST; INHIBITORS; BIS; CONVENIENT; FACILE; ROUTE;

D O I：

10.1080/00397911.2019.1584675

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of acylated alpha-aminophosphine oxides were synthesized by the microwave-assisted Kabachnik-Fields reaction of a series of carboxylic acid amides, formaldehyde and secondary phosphine oxides. To compensate the lower reactivity of the -NH2 reagents, they had to be used in an excess. The solvolytic condensations furnished the alpha-aminophosphine oxides in yields of 58-93% after purification by chromatography.

引用

页码：1047 / 1054

页数：8

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