Microwave-assisted synthesis of α-aminophosphine oxides by the Kabachnik-Fields reaction applying amides as the starting materials

被引：10
|
作者：
Tripolszky, Anna [1 ]
Zoboki, Lili [1 ]
Balint, Erika [1 ]
Koti, Janos [2 ]
Keglevich, Gyorgy [1 ]
机构：
[1] Budapest Univ Technol & Econ, Dept Organ Chem & Technol, H-1521 Budapest, Hungary
[2] Gedeon Richter Plc, Budapest, Hungary
来源：
SYNTHETIC COMMUNICATIONS | 2019年 / 49卷 / 08期
关键词：
alpha-Aminophosphine oxides; carboxylic acid amides; Kabachnik-Fields reaction; microwave; AMINO PHOSPHONATES; SOLVENT-FREE; IONIC LIQUID; EFFICIENT; CATALYST; INHIBITORS; BIS; CONVENIENT; FACILE; ROUTE;
D O I：
10.1080/00397911.2019.1584675
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of acylated alpha-aminophosphine oxides were synthesized by the microwave-assisted Kabachnik-Fields reaction of a series of carboxylic acid amides, formaldehyde and secondary phosphine oxides. To compensate the lower reactivity of the -NH2 reagents, they had to be used in an excess. The solvolytic condensations furnished the alpha-aminophosphine oxides in yields of 58-93% after purification by chromatography.
引用
收藏
页码：1047 / 1054
页数：8
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