Phosphorylation-Dependent SUMOylation of the Transcription Factor NF-E2

被引：11
|
作者：
Su, Yee-Fun [1 ]
Shyu, Yu-Chiau [3 ,4 ]
Shen, Che-Kun James [1 ]
Hwang, Jaulang [1 ,2 ]
机构：
[1] Acad Sinica, Inst Mol Biol, Taipei, Taiwan
[2] Taipei Med Univ, Sch Med, Dept Biochem, Taipei, Taiwan
[3] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei 112, Taiwan
[4] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan
来源：
PLOS ONE | 2012年 / 7卷 / 09期
关键词：
ERYTHROLEUKEMIA CELL-DIFFERENTIATION; LEUCINE-ZIPPER PROTEIN; SUMO MODIFICATION; GENE-EXPRESSION; TOPOISOMERASE-I; REPRESSION; PATHWAYS; KINASE; JUN;
D O I：
10.1371/journal.pone.0044608
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Nuclear factor erythroid-derived 2 (NF-E2), a heterodimer composed of p45 and p18, is a transcriptional activator in hematopoietic progenitors. The transcriptional activity of NF-E2 is not only upregulated by SUMOylation but also stimulated by the cAMP-dependent protein kinase A (PKA). However, the relationship between SUMOylation and phosphorylation in the activation of NF-E2 is unclear. In the present studies, we have demonstrated that PKA enhances NF-E2 SUMOylation in an in vitro system using purified proteins, suggesting a possible mechanism for PKA-dependent activation of the NF-E2 transcription factor through SUMOylation.
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收藏
页数：7
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