Temperature-sensitive mutations for live-attenuated Rift Valley fever vaccines: implications from other RNA viruses

被引：4
|
作者：
Nishiyama, Shoko [1 ]
Ikegami, Tetsuro [1 ,2 ,3 ]
机构：
[1] Univ Texas Med Branch, Dept Pathol, MMNP3-206D,301 Univ Blvd, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA
[3] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA
来源：
FRONTIERS IN MICROBIOLOGY | 2015年 / 6卷
关键词：
Rift Valley fever virus; bunyavirus; vaccine; MP-12; temperature sensitivity; AMINO-ACID SUBSTITUTION; TO-ALANINE MUTAGENESIS; NSS PROTEIN; MOLECULAR EPIDEMIOLOGY; TRANSCRIPTION FACTOR; RHESUS MACAQUES; MP-12; VACCINE; HOST-RANGE; MUTANTS; GENE;
D O I：
10.3389/fmicb.2015.00787
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Rift Valley fever (RVF) is a mosquito-borne zoonotic disease endemic to the African continent. RVF is characterized by high rate of abortions in ruminants and hemorrhagic fever, encephalitis, or blindness in humans. RVF is caused by the Rift Valley fever virus (RVFV: genus Phlebovirus, family Bunyaviridae). Vaccination is the only known effective strategy to prevent the disease, but there are no licensed RVF vaccines available for humans. A live-attenuated vaccine candidate derived from the wild-type pathogenic Egyptian ZH548 strain, MP-12, has been conditionally licensed for veterinary use in the U.S. MP-12 displays a temperature-sensitive (ts) phenotype and does not replicate at 41 degrees C. The ts mutation limits viral replication at a specific body temperature and may lead to an attenuation of the virus. Here we will review well-characterized ts mutations for RNA viruses, and further discuss the potential in designing novel live-attenuated vaccines for RVF.
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页数：8
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