Glucagon's yin and yang effects on hepatic glucose production

被引：6

作者：

Edgerton, Dale S. ^{[1
]}

Cherrington, Alan D. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA

来源：

NATURE MEDICINE | 2013年 / 19卷 / 06期

关键词：

CONSCIOUS DOG; HYPERGLYCEMIA; METABOLISM; INSULIN; LIVER; RAT;

D O I：

10.1038/nm.3202

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New insights into the actions of the hormone glucagon are provided by a recent study in rodents, which shows that glucagon can suppress hepatic glucose production by acting through the mediobasal hypothalamic region of the brain. This central regulatory mechanism is impaired in rats fed a high-fat diet, suggesting that hypothalamic glucagon resistance may be relevant to the hyperglycemia observed in obesity, diabetes or both (pages 766-772).

引用

页码：674 / 675

页数：2

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