Glucagon's yin and yang effects on hepatic glucose production

被引：6
|
作者：
Edgerton, Dale S. [1 ]
Cherrington, Alan D. [1 ]
机构：
[1] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA
来源：
NATURE MEDICINE | 2013年 / 19卷 / 06期
关键词：
CONSCIOUS DOG; HYPERGLYCEMIA; METABOLISM; INSULIN; LIVER; RAT;
D O I：
10.1038/nm.3202
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New insights into the actions of the hormone glucagon are provided by a recent study in rodents, which shows that glucagon can suppress hepatic glucose production by acting through the mediobasal hypothalamic region of the brain. This central regulatory mechanism is impaired in rats fed a high-fat diet, suggesting that hypothalamic glucagon resistance may be relevant to the hyperglycemia observed in obesity, diabetes or both (pages 766-772).
引用
收藏
页码：674 / 675
页数：2
相关论文
共 50 条
  • [1] Glucagon's yin and yang effects on hepatic glucose production
    Dale S Edgerton
    Alan D Cherrington
    Nature Medicine, 2013, 19 : 674 - 675
  • [2] DYNAMICS OF GLUCAGON ACTION ON HEPATIC GLUCOSE PRODUCTION
    KELLER, N
    URQUHART, J
    YATES, FE
    FEDERATION PROCEEDINGS, 1972, 31 (02) : A263 - &
  • [3] EFFECTS OF STIMULATION OF INSULIN AND GLUCAGON-SECRETION ON HEPATIC GLUCOSE PRODUCTION, INSULIN-GLUCAGON RATIO AND HEPATIC EXTRACTION OF INSULIN AND GLUCAGON
    FIELD, JB
    BLOOM, G
    PETRUSKA, M
    BROSKIN, K
    CHOU, C
    CLINICAL RESEARCH, 1976, 24 (03): : A485 - A485
  • [4] Korea's yin and yang
    Nature Materials, 2007, 6 : 703 - 703
  • [5] Korea's yin and yang
    不详
    NATURE MATERIALS, 2007, 6 (10) : 703 - 703
  • [6] In vivo interaction of epinephrine and glucagon on hepatic glucose production
    Sherck, SM
    Chu, CAN
    Farmer, B
    Yang, Y
    Donahue, EP
    Cherrington, AD
    DIABETES, 2000, 49 : A289 - A289
  • [7] Hypothalamic glucagon signaling inhibits hepatic glucose production
    Patricia I Mighiu
    Jessica T Y Yue
    Beatrice M Filippi
    Mona A Abraham
    Madhu Chari
    Carol K L Lam
    Clair S Yang
    Nikita R Christian
    Maureen J Charron
    Tony K T Lam
    Nature Medicine, 2013, 19 : 766 - 772
  • [8] Hypothalamic glucagon signaling inhibits hepatic glucose production
    Mighiu, Patricia I.
    Yue, Jessica T. Y.
    Filippi, Beatrice M.
    Abraham, Mona A.
    Chari, Madhu
    Lam, Carol K. L.
    Yang, Clair S.
    Christian, Nikita R.
    Charron, Maureen J.
    Lam, Tony K. T.
    NATURE MEDICINE, 2013, 19 (06) : 766 - +
  • [9] GLUCAGON AS A REGULATOR OF HEPATIC GLUCOSE-PRODUCTION INVIVO
    CHERRINGTON, AD
    STEVENSON, RW
    STEINER, KE
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1987, 15 (06) : 1023 - 1027
  • [10] The effects of a specific glucagon antagonist on glucagon stimulated glucose production
    Petersen, KF
    Sullivan, JT
    Amatruda, JM
    Livingston, JN
    Shulman, GI
    DIABETOLOGIA, 1999, 42 : A42 - A42
12345