Synthesis of 3-substituted 4-hydroxyquinolin-2-ones via C-acylation reactions of active methylene compounds with functionalized 3,1-benzoxazin-4-ones

被引：0
|
作者：
Mitsos, C [1 ]
Zografos, A [1 ]
Igglessi-Markopoulou, O [1 ]
机构：
[1] Natl Tech Univ Athens, Dept Chem Engn, Organ Chem Lab, GR-15773 Athens, Greece
来源：
HETEROCYCLES | 1999年 / 51卷 / 07期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A general protocol for the construction of 4-hydroxyquinolin-2-ones is described. Benzoxazinones react with the anion of active methylene compounds to produce the functionalized C-acylation componnds in very good yields. These key intermediates are cyclized to the desired quinolinones (25-40) under basic conditions. Spectral data and physical characteristics for all compounds are reported.
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页码：1543 / +
页数：20
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