Recent Advances in Synthetic Methods for Radioiodination

被引：46

作者：

Dubost, Emmanuelle ^{[2
]}

McErlain, Holly ^{[1
]}

Babin, Victor ^{[2
]}

Sutherland, Andrew ^{[1
]}

Cailly, Thomas ^{[2
,3
,4
]}

机构：

[1] Univ Glasgow, Sch Chem, WestCHEM, Joseph Black Bldg, Glasgow G12 8QQ, Lanark, Scotland

[2] Normandie Univ, UNICAEN, Ctr Etud & Rech Medicament Normandie CERMN, F-14000 Caen, France

[3] Normandie Univ, UNICAEN, IMOGERE, F-14000 Caen, France

[4] CHU Cote Nacre, Dept Nucl Med, F-14000 Caen, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 13期

关键词：

ARYL IODIDES; IODINATION; ANALOGS; RADIOSYNTHESIS; EFFICIENT; THERAPY; TRACERS; RADIOTRACERS; COMPLEXES; REAGENTS;

D O I：

10.1021/acs.joc.0c00644

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organic compounds bearing radioisotopes of iodine are widely used for biological research, diagnostic imaging, and radiotherapy. Early reported synthetic methods for the incorporation of radioiodine have generally involved high temperature reactions or strongly oxidizing conditions. To overcome these limitations and to cope with the demand for novel radioiodinated probes, there has been a surge in the development of new synthetic methodology for radioiodination. This synopsis describes the key transformations developed recently.

引用

页码：8300 / 8310

页数：11

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