Frequency analysis of the CCR5Δ32 mutation in patients with brucellosis

被引：7
|
作者：
Skendros, P
Boura, P
Tsantas, N
Debre, P
Theodorou, I
机构：
[1] Aristotle Univ Thessaloniki, Hippokrat Hosp, Dept Internal Med 2, Clin Immunol Lab, Thessaloniki 54642, Greece
[2] Aristotle Univ Thessaloniki, Dept Math, Sect Stat Probabil & OR, GR-54006 Thessaloniki, Greece
[3] Hop La Pitie Salpetriere, INSERM, UR543, Lab Cent Immunol Cellulaire & Tissulaire, Paris, France
来源：
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES | 2002年 / 34卷 / 12期
关键词：
D O I：
10.1080/0036554021000026975
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
This study investigated the influence of the host's CCR5 genotype in human brucellosis. Genotype analysis for the CCR5Delta32 mutation was performed in 185 brucellosis patients and 141 healthy volunteers, all recruited in northern Greece. In the brucellosis-infected patients the CCR5Delta32 genotype distribution showed a significant deviation from the Hardy-Weinberg equilibrium ( p = 0.030), owing to the presence of 2 individuals homozygous for Delta32 among the 185 brucellosis patients compared with none of the 141 controls. Extended studies should be performed to confirm an association between CCR5 genotype and the risk of acquiring brucellosis.
引用
收藏
页码：944 / 946
页数：3
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