Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill

被引：59

作者：

Wang, Yifeng ^{[1
]}

Wang, Haojiang ^{[1
]}

Jiang, Yidong ^{[1
]}

Zhang, Cheng ^{[1
]}

Shao, Juanjuan ^{[1
]}

Xu, Danqian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Key Lab Green Pesticides & Cleaner Prod Technol Z, Hangzhou 310014, Zhejiang, Peoples R China

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 07期

基金：

中国国家自然科学基金;

关键词：

ASYMMETRIC FLUORINATION; MEDICINAL CHEMISTRY; KETOESTERS; MECHANOCHEMISTRY; TRIFLUOROMETHYLATION; PHARMACEUTICALS; ORGANOCATALYSIS; CHLORINATION; DERIVATIVES; MONO;

D O I：

10.1039/c6gc03306g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fast and highly enantioselective fluorination of beta-keto esters catalyzed by diphenylamine linked bis(oxazoline)-Cu(OTf)(2) complexes under solvent-free conditions has been developed using a planetary ball mill. High yields, high enantioselectivities and shorter reaction times were achieved with low catalyst loading.

引用

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页码：1674 / 1677

页数：4

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