Fast, solvent-free and highly enantioselective fluorination of β-keto esters catalyzed by chiral copper complexes in a ball mill

被引：59
|
作者：
Wang, Yifeng [1 ]
Wang, Haojiang [1 ]
Jiang, Yidong [1 ]
Zhang, Cheng [1 ]
Shao, Juanjuan [1 ]
Xu, Danqian [1 ]
机构：
[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Key Lab Green Pesticides & Cleaner Prod Technol Z, Hangzhou 310014, Zhejiang, Peoples R China
来源：
GREEN CHEMISTRY | 2017年 / 19卷 / 07期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC FLUORINATION; MEDICINAL CHEMISTRY; KETOESTERS; MECHANOCHEMISTRY; TRIFLUOROMETHYLATION; PHARMACEUTICALS; ORGANOCATALYSIS; CHLORINATION; DERIVATIVES; MONO;
D O I：
10.1039/c6gc03306g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A fast and highly enantioselective fluorination of beta-keto esters catalyzed by diphenylamine linked bis(oxazoline)-Cu(OTf)(2) complexes under solvent-free conditions has been developed using a planetary ball mill. High yields, high enantioselectivities and shorter reaction times were achieved with low catalyst loading.
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页码：1674 / 1677
页数：4
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