Histological and Histomorphometrical Determination of the Biogradation of -Tricalcium Phosphate Granules in Maxillary Sinus Floor Augmentation: A Prospective Observational Study

Introduction:We have recently used highly pure -TCP (beta-tricalcium phosphate) as the bone grafting material to avoid highly invasive autogenous bone grafting. We evaluated the osseoconduction potential of highly pure -TCP in sinus augmentation surgery treatment.Materials and Methods:The study group comprised 13 patients who underwent maxillary sinus floor augmentation with -TCP alone. Seven patients underwent sinus augmentation and implant placement simultaneously. Six patients were treated with a staged approach. Six months after surgery, specimens were obtained from 7 patients (for lateral biopsy) and 6 patients (for vertical biopsy).Results:Histological and histomorphometrical analysis showed a mean bone proportion of 30.8% (vertical) and 12.0% (lateral) for new bone formation and good integration of the -TCP. New bone formation was lower in the lateral biopsy specimens than in the vertical.Conclusion:Highly pure -TCP is a safe bone-grafting material with superior osteoconductive properties. Histologic and radiographic examinations indicate that -TCP is slowly resorbed, which results in unresorbed graft material remaining even 6 months after the procedure, and that new bone replacement occurs slowly for approximately 1 year.