The Effect of Safflower Yellow on Spinal Cord Ischemia Reperfusion Injury in Rabbits

被引：25

作者：

Zhou, Daiwei ^{[1
]}

Liu, Bingbing ^{[1
]}

Xiao, Xiaoshan ^{[1
]}

Dai, Peng ^{[2
]}

Ma, Songmei ^{[1
]}

Huang, Weihua ^{[1
]}

机构：

[1] Guangdong Prov Emergency Hosp, Dept Anesthesiol, Guangdong Prov Peoples Hosp 2, Guangzhou 0086510317, Guangdong, Peoples R China

[2] Foshan First Peoples Hosp, Dept Anesthesiol, Guangzhou 0086510317, Guangdong, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2013年 / 2013卷

关键词：

D O I：

10.1155/2013/692302

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation.

引用

页数：9

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