Thymosin β4 sustained release from poly(lactide-co-glycolide) microspheres: synthesis and implications for treatment of myocardial ischemia

被引：3

作者：

Thatcher, Jeffrey E. ^{[1
,2
]}

Welch, Tre ^{[3
]}

Eberhart, Robert C. ^{[2
,3
]}

Schelly, Zoltan A. ^{[4
]}

DiMaio, J. Michael ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Cardiothorac Surg, Dallas, TX 75390 USA

[2] Univ Texas Arlington, Dept Biomed Engn, Arlington, TX 76019 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Surg, Dallas, TX 75390 USA

[4] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

THYMOSINS IN HEALTH AND DISEASE II | 2012年 / 1270卷

关键词：

controlled; sustained; release; microsphere; thymosin beta 4; heart; FIBROBLAST-GROWTH-FACTOR; PROTEIN RELEASE; POLY(D; L-LACTIC-CO-GLYCOLIC ACID); TISSUE DISTRIBUTION; TETANUS VACCINE; CELL-MIGRATION; RAT MODEL; PDGF-BB; DELIVERY; ANGIOGENESIS;

D O I：

10.1111/j.1749-6632.2012.06681.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A sustained release formulation for the therapeutic peptide thymosin beta 4 (T beta 4) that can be localized to the heart and reduce the concentration and frequency of dose is being explored as a means to improve its delivery in humans. This review contains concepts involved in the delivery of peptides to the heart and the synthesis of polymer microspheres for the sustained release of peptides, including T beta 4. Initial results of poly(lactic-co-glycolic acid) microspheres synthesized with specific tolerances for intramyocardial injection that demonstrate the encapsulation and release of T beta 4 from double-emulsion microspheres are also presented.

引用

页码：112 / 119

页数：8

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