Depth matters: cells grown on nano-porous anodic alumina respond to pore depth

被引：8

作者：

Thakur, S. ^{[1
]}

Massou, S. ^{[1
]}

Benoliel, A. M. ^{[2
]}

Bongrand, P. ^{[2
]}

Hanbucken, M. ^{[1
]}

Sengupta, K. ^{[1
]}

机构：

[1] Univ Aix Marseille, CNRS CINaM UPR 7325, Marseille 9, France

[2] Univ Aix Marseille 2, UMR CNRS 6212, UMR INSERM 600, F-13288 Marseille 9, France

来源：

NANOTECHNOLOGY | 2012年 / 23卷 / 25期

关键词：

FABRICATION; ADHESION; MEMBRANES; SURFACES; ARRAYS; FATE; DIFFERENTIATION; NANOTOPOGRAPHY; ACTIVATION; TEMPLATES;

D O I：

10.1088/0957-4484/23/25/255101

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Recent experiments have shown unambiguously that living cells respond to the nano-topography of surfaces they grow on-specifically, the fate of stem cells grown on nano-porous titania or alumina have been shown to be decided by the pore size. However, most experiments have focused on pore size or pitch. Here we show that in addition to pore size and pitch, the depth of the pores has a profound effect on cell morphology and the arrangement of the actin cytoskeleton.

引用

页数：6

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