Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment

被引：31
|
作者：
Sasidharan, Sreenivasan [1 ]
Logeswaran, Selvarasoo [2 ]
Latha, Lachimanan Yoga [1 ]
机构：
[1] Univ Sains Malaysia, Inst Res Mol Med INFORMM, Usm 11800, Pulau Pinang, Malaysia
[2] Asian Inst Med Sci & Technol, Fac Sci Appl, Dept Biotechnol, Sungai Petani 08000, Kedah, Malaysia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 01期
关键词：
Elaeis guineensis; wound healing activity; matrix metalloproteinases; gelatin zymography; LEAVES;
D O I：
10.3390/ijms13010336
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.
引用
收藏
页码：336 / 347
页数：12
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