Wound Healing Activity of Elaeis guineensis Leaf Extract Ointment

被引：31
|
作者：
Sasidharan, Sreenivasan [1 ]
Logeswaran, Selvarasoo [2 ]
Latha, Lachimanan Yoga [1 ]
机构：
[1] Univ Sains Malaysia, Inst Res Mol Med INFORMM, Usm 11800, Pulau Pinang, Malaysia
[2] Asian Inst Med Sci & Technol, Fac Sci Appl, Dept Biotechnol, Sungai Petani 08000, Kedah, Malaysia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 01期
关键词：
Elaeis guineensis; wound healing activity; matrix metalloproteinases; gelatin zymography; LEAVES;
D O I：
10.3390/ijms13010336
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Elaeis guineensis of the Arecaceae family is widely used in the traditional medicine of societies in West Africa for treating various ailments. To validate the ethnotherapeutic claims of the plant in skin diseases, wound healing activity was studied. The results showed that E. guineensis leaf extract had potent wound healing capacity as evident from the better wound closure (P < 0.05), improved tissue regeneration at the wound site, and supporting histopathological parameters pertaining to wound healing. Matrix metalloproteinases expression correlated well with the results thus confirming efficacy of E. guineensis in the treatment of the wound. E. guineensis accelerated wound healing in rats, thus supporting its traditional use. The result of this study suggested that, used efficiently, oil palm leaf extract is a renewable resource with wound healing properties.
引用
收藏
页码：336 / 347
页数：12
相关论文
共 50 条
  • [1] Antioxidant Activity of Elaeis guineensis Leaf Extract: An Alternative Nutraceutical Approach in Impeding Aging.
    Soundararajan, Vijayarathna
    Sreenivasan, Sasidharan
    [J]. 3RD INTERNATIONAL CONFERENCE ON BIOTECHNOLOGY AND FOOD SCIENCE (ICBFS 2012), 2012, 2 : 153 - 159
  • [2] POTENTIAL USES OF OIL PALM (Elaeis guineensis) LEAF EXTRACT IN TOPICAL APPLICATION
    Yusof, Nor Zuliana
    Abd Gani, Siti Salwa
    Siddiqui, Yasmeen
    Mokhtar, Nor Fadzillah Mohd
    Hasan, Zafarizal Aldrin Azizul
    [J]. JOURNAL OF OIL PALM RESEARCH, 2016, 28 (04): : 520 - 530
  • [3] Wound Healing Activity of Ethanol Leaf Extract of Erythrina senegalensis
    Ilodigwe, E. E.
    Okonkwo, B. E.
    Agbata, C. A.
    Ajaghaku, D. L.
    Eze, P. M.
    [J]. BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 4 (04): : 531 - 540
  • [4] Wound healing activity of Glycosmis arborea leaf extract in rats
    Silambujanaki, P.
    Chandra, Ch Bala Tejo
    Kumar, K. Anil
    Chitra, V.
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2011, 134 (01) : 198 - 201
  • [5] ANTIMICROBIAL ACTIVITY OF ELAEIS GUINEENSIS LEAF EXTRACT AGAINST GANODERMA BONINENSE OF OIL PALM BASAL STEM ROT
    Lee, Elaine H. C.
    Chong, K. P.
    [J]. PAKISTAN JOURNAL OF BOTANY, 2015, 47 (04) : 1593 - 1597
  • [6] Wound Healing Potential of Elaeis guineensis Jacq Leaves in an Infected Albino Rat Model
    Sasidharan, Sreenivasan
    Nilawatyi, Rajoo
    Xavier, Rathinam
    Latha, Lachimanan Yoga
    Amala, Rajoo
    [J]. MOLECULES, 2010, 15 (05) : 3186 - 3199
  • [7] Evaluation of cutaneous wound healing activity of Ocimum basilicum aqueous extract ointment in rats
    Zangeneh M.M.
    Zangeneh A.
    Seydi N.
    Moradi R.
    [J]. Comparative Clinical Pathology, 2019, 28 (5) : 1447 - 1454
  • [8] Wound-healing activity of bialm ointment
    Rakhimov K.D.
    Pak R.N.
    Tekhneryadnov A.V.
    Adekenov S.M.
    Kul'zhanov Z.K.
    Kim T.D.
    Koishibaev B.G.
    [J]. Pharmaceutical Chemistry Journal, 2000, 34 (9) : 511 - 513
  • [9] wound healing activity of Morinda tinctoria Roxb aqueous leaf extract
    RajKumar, S. Rex Jeya
    Gnanavel, G.
    Nadar, M. S. A. Muthukumar
    Sankaranarayanan, Rajkumar
    [J]. 3 BIOTECH, 2018, 8 (08)
  • [10] AN in vitro STUDY OF WOUND HEALING ACTIVITY OF Ficus deltoidea LEAF EXTRACT
    Mustaffa, Nurul Ain Aqilla Wan
    Hasham, Rosnani
    Sarmidi, Mohamad Roji
    [J]. JURNAL TEKNOLOGI-SCIENCES & ENGINEERING, 2015, 77 (03):
12345