Monitoring the acoustic activity of a pharmaceutical powder during roller compaction

被引：15
|
作者：
Salonen, J
Salmi, K
Hakanen, A
Laine, E
Linsaari, K
机构：
[1] UNIV TURKU,DEPT PHYS,FIN-20014 TURKU,FINLAND
[2] ORION CORP,ORION PHARMA,FIN-20101 TURKU,FINLAND
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 153卷 / 02期
关键词：
acoustic emission; Gaussian function; lamination; pharmaceutical powder; roller compaction;
D O I：
10.1016/S0378-5173(97)00086-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Acoustic relaxation emissions (ARE) from microcrystalline cellulose (MC) and maize starch (MS) were detected during roller compaction using a microphone with flat frequency response up to 20 kHz and a tunable high pass filter the limiting frequency of which was set at 15 kHz. The noise from the compactor itself was found to appear mainly below 15 kHz. The ARE intensity of MC was observed to increase as a function of applied compressive force up to 45 kN, while the ARE intensity-force curve of MS had a maximum at 50 kN. A Gaussian-shaped function fitted reasonably to the data in both cases. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：257 / 261
页数：5
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