A Practical Electrochemical Sensor for Atenolol Detection Based on a Graphene Oxide Composite Film Doped with Zinc Oxide Nanoparticles

Zinc oxide nanoparticles doped graphene oxide modified glassy carbon electrodes (Zn-GO/GCE) were fabricated for easy, cheap and practical detection of atenolol (ATE). The morphological and chemical characterizations of modified electrodes were carried out with scanning electron microscopy (SEM), electron diffraction spectroscopy (EDS) and X-Ray photoelectron spectroscopy (XPS). The amounts of the electrode modifiers and the differential pulse voltammetric parameters were optimized due to exhibited the best analytical response towards the determination of ATE. As a result, the calibration curves of ATE were obtained at Zn-GO/GCE using DPV technique with two different linear parts: 7.8 - 84 mu mol L(-1)and 167 mu mol L-1- 639 mu mol L-1. The detection limit (LOD) was also calculated as 2.50 mu mol L-1. The fabricated electrode in this study is selective for ATE in the presence of some electroactive molecules. The practical, easy and cheap modified electrode was applied for the detection of ATE in atenolol medicine tablets with good recovery.