Receptor conformational change induces fluoride binding despite competitive water binding

被引：25
|
作者：
Trembleau, Laurent [1 ]
Smith, Tim A. D. [2 ]
Abdelrahman, Mostafa H. [3 ]
机构：
[1] Univ Aberdeen, Sch Nat & Comp Sci, Aberdeen AB24 3UE, Scotland
[2] Univ Aberdeen, Sch Med & Dent, Aberdeen AB25 2ZD, Scotland
[3] Assiut Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Assiut 71524, Egypt
来源：
CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 52期
基金：
英国生物技术与生命科学研究理事会;
关键词：
ION COMPLEXATION; ANION; HIGHLIGHTS; CHEMISTRY; BORANE;
D O I：
10.1039/c3cc43019g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Fluoride binding by artificial receptors in water remains a challenging task due to the high hydration enthalpy of this anion. A novel cationic boron-based tripodal receptor featuring three flexible ammonium-containing arms has been prepared. NMR spectroscopy studies show that the receptor is capable of binding selectively the fluoride anion with high affinity in acidic water.
引用
收藏
页码：5850 / 5852
页数：3
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