Effects of Natural Products on Mcl-1 Expression and Function

被引：14
|
作者：
Muller, Florian [1 ]
Cerella, Claudia [1 ]
Radogna, Flavia [1 ]
Dicato, Mario [1 ]
Diederich, Marc [2 ]
机构：
[1] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, L-2540 Luxembourg, Luxembourg
[2] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
来源：
CURRENT MEDICINAL CHEMISTRY | 2015年 / 22卷 / 30期
基金：
新加坡国家研究基金会;
关键词：
apoptosis; cancer; Mcl-1; natural compounds; TRAIL-INDUCED APOPTOSIS; HUMAN MULTIPLE-MYELOMA; DOWN-REGULATES MCL-1; BCL-2 PROTEIN FAMILY; CELL-DEATH; SIGNAL TRANSDUCER; TARGETING MCL-1; PROSTATE-CANCER; INHIBITION; ACTIVATOR;
D O I：
10.2174/0929867322666150716115435
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer development is mostly due to a deregulation of cell death as cancer cells become resistant to apoptosis by increasing expression of anti-apoptotic proteins belonging to the Bcl-2 family. Mcl-1 is one anti-apoptotic protein, which is mainly responsible for cancer cell resistance as it is overexpressed by most cancer cell types. Many research projects aim to restore cancer cell death by using natural pharmacological scaffolds targeting anti-apoptotic proteins to inhibit their effect in cancer development. This review introduces natural compound inhibitors of the Bcl-2 protein family with a focus on Mcl-1.
引用
收藏
页码：3447 / 3461
页数：15
相关论文
共 50 条
  • [21] Regulation of apoptosis by Mcl-1
    Edwards, S. W.
    Thomas, L. W.
    Lam, C. W.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2010, 40 : 35 - 35
  • [22] Unraveling MCL-1 degradation
    Opferman, J. T.
    CELL DEATH AND DIFFERENTIATION, 2006, 13 (08): : 1260 - 1262
  • [23] Seeking a MCL-1 inhibitor
    G Brumatti
    P G Ekert
    Cell Death & Differentiation, 2013, 20 : 1440 - 1441
  • [24] Mcl-1 Ubiquitination and Destruction
    Inuzuka, Hiroyuki
    Fukushima, Hidefumi
    Shaik, Shavali
    Liu, Pengda
    Lau, Alan W.
    Wei, Wenyi
    ONCOTARGET, 2011, 2 (03) : 239 - 244
  • [25] Seeking a MCL-1 inhibitor
    Brumatti, G.
    Ekert, P. G.
    CELL DEATH AND DIFFERENTIATION, 2013, 20 (11): : 1440 - 1441
  • [26] Differential effects of aging on MCL-1 and caspase 3 expression in murine small and large intestine
    Reddix, Rhoda A.
    Hans, Chetan
    Boulares, Hamid
    Lucchesi, Pamela A.
    FASEB JOURNAL, 2007, 21 (06): : A808 - A808
  • [27] The dual effects of TNFα on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1
    Cross, Andrew
    Moots, Robert J.
    Edwards, Steven W.
    BLOOD, 2008, 111 (02) : 878 - 884
  • [28] The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
    Stewart M.L.
    Fire E.
    Keating A.E.
    Walensky L.D.
    Nature Chemical Biology, 2010, 6 (8) : 595 - 601
  • [29] The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
    Stewart, Michelle L.
    Fire, Emiko
    Keating, Amy E.
    Walensky, Loren D.
    NATURE CHEMICAL BIOLOGY, 2010, 6 (08) : 595 - 601
  • [30] MCL-1 expression of non-small cell lung cancer as a prognostic factor and MCL-1 as a promising target for gene therapy.
    Nakano, Takayuki
    Liu, Dage
    Nakashima, Nariyasu
    Yokomise, Hiroyasu
    Nii, Kazuhito
    Go, Tetsuhiko
    Tarumi, Shintaro
    Matsuura, Natsumi
    Chang, Sung Soo
    Fujiwara, Atsushi
    Kakehi, Yoshiyuki
    JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (15)
12345