One-pot Three-component Route for the Synthesis of Functionalized 4H-chromenes Catalyzed by ZrOCl2•8H2O in Water

被引：13

作者：

Halimehjani, Azim Ziyaei ^{[1
]}

Keshavarzi, Nahid ^{[2
]}

机构：

[1] Kharazmi Univ, Fac Chem, 49 Mofateh St, Tehran, Iran

[2] Sharif Univ Technol, Dept Chem, POB 11465-9516, Tehran, Iran

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 02期

关键词：

BETA-AMINO KETONES; IN-VITRO; MULTICOMPONENT REACTIONS; SELECTIVE SYNTHESIS; DOMINO REACTIONS; NAPHTHOPYRAN DERIVATIVES; CONJUGATE ADDITION; EFFICIENT; CHROMENES; ACID;

D O I：

10.1002/jhet.3081

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of functionalized 4H-chromenes via a one-pot three-component condensation reaction of a 2-hydroxybenzaldehyde with an active methylene compound and a carbon-based nucleophile in the presence of a catalytic amount of ZrOCl(2)8H(2)O in water under thermal condition has been described. High yields, simple work-up procedure, performing reactions in water and synthesis of complex molecules with a one-pot procedure are the main advantages of this procedure. In addition, the structure of the product from the condensation of salicylaldehyde, 2-naphthol, and dimedone was confirmed by X-ray crystallography.

引用

页码：522 / 529

页数：8

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