Safety and Feasibility of Remote Limb Ischemic Preconditioning in Patients With Unilateral Middle Cerebral Artery Stenosis and Healthy Volunteers

被引：30
|
作者：
Li, Sijie [1 ]
Ma, Chun [2 ]
Shao, Guo [2 ]
Esmail, Fatema [3 ]
Hua, Yang [4 ]
Jia, Lingyun [4 ]
Qin, Jian [1 ]
Ren, Changhong [2 ]
Luo, Yumin [2 ]
Ding, Yuchun [3 ]
Borlongang, Cesario V. [5 ]
Ji, Xunming [2 ,6 ]
机构：
[1] Capital Med Univ, Xuan Wu Hosp, Emergency Dept, Beijing, Peoples R China
[2] Capital Med Univ, Inst Hypoxia Med, Xuan Wu Hosp, Beijing, Peoples R China
[3] Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA
[4] Capital Med Univ, Xuan Wu Hosp, Vasc Ultrasound Div, Beijing, Peoples R China
[5] Univ S Florida, Morsani Coll Med, Dept Neurosurg & Brain Repair, Tampa, FL USA
[6] Capital Med Univ, Xuan Wu Hosp, Dept Neurosurg, Beijing, Peoples R China
来源：
CELL TRANSPLANTATION | 2015年 / 24卷 / 09期
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
Ischemic preconditioning (IPC); Blood pressure (BP); Middle cerebral artery (MCA) stenosis; Clinical trial; Stem cells; RANDOMIZED-CONTROLLED-TRIAL; TRANSCRANIAL DOPPLER; CLINICAL-APPLICATION; FLOW VELOCITY; STEM-CELLS; HYPOXIA; INJURY; BRAIN; TRANSPLANTATION; PROTECTION;
D O I：
10.3727/096368914X683520
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Previous studies have indicated a neuroprotective effect of remote limb ischemic preconditioning. The aim of the present study was to assess whether upper arm ischemic preconditioning is feasible and safe in patients with unilateral middle cerebral artery (MCA) stenosis compared to healthy volunteers. Ten patients with unilateral MCA stenosis and 24 healthy volunteers underwent limb ischemic preconditioning, consisting of five cycles of 5-min inflations of a blood pressure cuff to 200 mmHg around an upper limb followed by 5 mm of reperfusion. Limb ischemic preconditioning has no significant effect on the heart rate, oxygenation index, or mean flow velocity in patients with unilateral MCA stenosis or healthy volunteers. However, healthy volunteers showed a reduction in blood pressure 30 min following reperfusion of the last cycle. Limb ischemic preconditioning was found to be safe and well tolerated in both patients and healthy volunteers. We highlight the potential of limb ischemic preconditioning as an adjunct to neuroprotective treatment.
引用
收藏
页码：1901 / 1911
页数：11
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