Identification of α amylase inhibitors from Syzygium cumini Linn seeds

被引：0
|
作者：
Karthic, K. [1 ]
Kirthiram, K. S. [1 ]
Sadasivam, S. [1 ]
Thayumanavan, B. [1 ]
Palvannan, T. [2 ]
机构：
[1] Kumaraguru Coll Technol, Dept Biotechnol, Coimbatore 641006, Tamil Nadu, India
[2] Periyar Univ, Dept Biochem, Salem 636011, India
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2008年 / 46卷 / 09期
关键词：
amylase inhibitor; diabetes mellitus; non-competitive inhibitor; porcine pancreatic alpha-amylase; Syzygium cumini;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aqueous extract of S. cumini or Eugenia jambolana seeds and Psidium guajava leaves showed higher inhibition against the porcine pancreatic alpha-amylase among the medicinal plants studied. The a-amylase inhibitors from S.cumini seeds were separated from the extract by preparative thin layer chromatography into fractions with different R-f values. The fraction with Rf value between 0.285 and 0.43, which showed maximum inhibitory activity, was eluted and analyzed through LC-MS. The compounds identified from the seed extract of S. cumini were betulinic acid and 3,5,7,4 '-tetrahydroxy flavanone, which were reported earlier from S. formosanum and other plants. Dixon plot showed that the inhibition was noncompetitive in nature.
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页码：677 / 680
页数：4
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