Detecting protein function and protein-protein interactions from genome sequences

被引：1221
|
作者：
Marcotte, EM
Pellegrini, M
Ng, HL
Rice, DW
Yeates, TO
Eisenberg, D
机构：
[1] Univ Calif Los Angeles, Dept Energy Lab Struct Biol & Mol Med, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Energy Lab Struct Biol & Mol Med, Dept Biol Chem, Los Angeles, CA 90095 USA
来源：
SCIENCE | 1999年 / 285卷 / 5428期
关键词：
D O I：
10.1126/science.285.5428.751
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A computational method is proposed for inferring protein interactions from genome sequences on the basis of the observation that some pairs of interacting proteins have homologs in another organism fused into a single protein chain. Searching sequences from many genomes revealed 6809 such putative protein-protein interactions in Escherichia coli and 45,502 in yeast. Many members of these pairs were confirmed as functionally related; computational filtering further enriches for interactions. Some proteins have links to several other proteins; these coupled links appear to represent functional interactions such as complexes or pathways. Experimentally confirmed interacting pairs are documented in a Database of interacting Proteins.
引用
收藏
页码：751 / 753
页数：3
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