Transition metal free α-C-alkylation of ketones using secondary alcohols

被引：22

作者：

Dambatta, Mubarak B. ^{[1
]}

Santos, Joseph ^{[1
]}

Bolt, Robert R. A. ^{[1
]}

Morrill, Louis C. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Main Bldg,Pk Pl, Cardiff CF10 3AT, Wales

来源：

TETRAHEDRON | 2020年 / 76卷 / 45期

关键词：

C-alklation; Alcohols; Transition metal free; CATALYZED N-ALKYLATION; AMINES; AMINATION; GREEN;

D O I：

10.1016/j.tet.2020.131571

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base-mediated alpha-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-alpha-C-alkylation in high isolated yields (23 examples, 65% average yield). (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：4

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