Transition metal free α-C-alkylation of ketones using secondary alcohols

被引：22
|
作者：
Dambatta, Mubarak B. [1 ]
Santos, Joseph [1 ]
Bolt, Robert R. A. [1 ]
Morrill, Louis C. [1 ]
机构：
[1] Cardiff Univ, Sch Chem, Cardiff Catalysis Inst, Main Bldg,Pk Pl, Cardiff CF10 3AT, Wales
来源：
TETRAHEDRON | 2020年 / 76卷 / 45期
关键词：
C-alklation; Alcohols; Transition metal free; CATALYZED N-ALKYLATION; AMINES; AMINATION; GREEN;
D O I：
10.1016/j.tet.2020.131571
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A base-mediated alpha-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-alpha-C-alkylation in high isolated yields (23 examples, 65% average yield). (C) 2020 Elsevier Ltd. All rights reserved.
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页数：4
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