The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux

被引：32
|
作者：
Reyes, CL [1 ]
Ward, A [1 ]
Yu, J [1 ]
Chang, G [1 ]
机构：
[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92137 USA
来源：
FEBS LETTERS | 2006年 / 580卷 / 04期
关键词：
multidrug resistance; ABC transporter; membrane protein; X-ray crystallography; MsbA; P-glycoprotein; LmrA;
D O I：
10.1016/j.febslet.2005.11.033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1042 / 1048
页数：7
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