Microwave-Assisted Synthesis of β-1,2,3-Triazolyl-α-amino Esters

被引：2

作者：

Khan, Amna N. ^{[1
]}

Vasconcelos, Stanley N. S. ^{[1
]}

Carrau, Gonzalo ^{[1
]}

Stefani, Helio A. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508000 Sao Paulo, SP, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2015年 / 26卷 / 07期

基金：

巴西圣保罗研究基金会;

关键词：

microwave; amino ester; click chemistry; addition reaction; 1,2,3-triazole; CLICK CHEMISTRY; HUISGEN CYCLOADDITION; LIGATION; LIBRARY; AZIDES;

D O I：

10.5935/0103-5053.20150114

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of ethyl (p-methoxyphenylimino) acetate with propargyl bromide mediated by activated zinc powder afforded alkynyl amine, which was then reacted with a variety of organic azides using a microwave energy source, leading to beta-1,2,3-triazolyl-alpha-amino esters in good yield.

引用

页码：1457 / 1465

页数：9

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