Microwave-Assisted Synthesis of β-1,2,3-Triazolyl-α-amino Esters

被引：2
|
作者：
Khan, Amna N. [1 ]
Vasconcelos, Stanley N. S. [1 ]
Carrau, Gonzalo [1 ]
Stefani, Helio A. [1 ]
机构：
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Farm, BR-05508000 Sao Paulo, SP, Brazil
来源：
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2015年 / 26卷 / 07期
基金：
巴西圣保罗研究基金会;
关键词：
microwave; amino ester; click chemistry; addition reaction; 1,2,3-triazole; CLICK CHEMISTRY; HUISGEN CYCLOADDITION; LIGATION; LIBRARY; AZIDES;
D O I：
10.5935/0103-5053.20150114
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of ethyl (p-methoxyphenylimino) acetate with propargyl bromide mediated by activated zinc powder afforded alkynyl amine, which was then reacted with a variety of organic azides using a microwave energy source, leading to beta-1,2,3-triazolyl-alpha-amino esters in good yield.
引用
收藏
页码：1457 / 1465
页数：9
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