Design of an Integrated Process of Chromatography, Crystallization and Racemization for the Resolution of 2′,6′-Pipecoloxylidide (PPX)

被引：19

作者：

von Langermann, Jan ^{[1
]}

Kaspereit, Malte ^{[2
]}

Shakeri, Mozaffar ^{[3
]}

Lorenz, Heike ^{[1
]}

Hedberg, Martin ^{[4
]}

Jones, Matthew J. ^{[4
]}

Larson, Kerstin ^{[4
]}

Herschend, Bjorn ^{[4
]}

Arnell, Robert ^{[4
]}

Temmel, Erik ^{[1
]}

Backvall, Jan-Erling ^{[3
]}

Kienle, Achim ^{[1
,5
]}

Seidel-Morgenstern, Andreas ^{[1
,6
]}

机构：

[1] Max Planck Inst Dynam Complex Tech Syst, D-39106 Magdeburg, Germany

[2] Univ Erlangen Nurnberg, Dept Separat Sci & Technol, D-91058 Erlangen, Germany

[3] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

[4] AstraZeneca AB, Pharmaceut Dev, Med Dev, S-15185 Sodertalje, Sweden

[5] Univ Magdeburg, Chair Automat Modeling, D-39106 Magdeburg, Germany

[6] Univ Magdeburg, Chair Chem & Proc Engn, D-39106 Magdeburg, Germany

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2012年 / 16卷 / 02期

关键词：

DYNAMIC KINETIC RESOLUTION; STATE RECYCLING CHROMATOGRAPHY; ENANTIOMERICALLY PURE AMINES; OPTIMIZATION; SEPARATION; CATALYSTS; EFFICIENT;

D O I：

10.1021/op200268h

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An integrated process for the chiral separation of the industrially relevant substance 2',6'-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %.

引用

页码：343 / 352

页数：10

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