Ancestral AAV Demonstrates Unique Transduction Properties in Mouse and Primate

被引：0
|
作者：
Carvalho, Livia S. [1 ]
Xiao, Ru [1 ]
Comander, Jason I. [2 ]
Kim, Leo A. [1 ,2 ]
Lim, Laurence [2 ]
Khaychuck, Vadim [1 ]
Plovie, Eva [1 ]
Zinn, Eric [1 ]
Vandenberghe, Luk H. [1 ]
机构：
[1] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Schepens Eye Res Inst, Boston, MA 02114 USA
[2] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA
来源：
MOLECULAR THERAPY | 2015年 / 23卷
关键词：
D O I：
10.1016/S1525-0016(16)33992-2
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
383
引用
收藏
页码：S152 / S153
页数：2
相关论文
共 50 条
  • [31] Comparative Transduction Efficiency of AAV Vector Serotypes 1-6 in the Substantia Nigra and Striatum of the Primate Brain
    Markakis, Eleni A.
    Vives, Kenneth P.
    Bober, Jeremy
    Leichtle, Stefan
    Leranth, Csaba
    Beecham, Jeff
    Elsworth, John D.
    Roth, Robert H.
    Samulski, R. Jude
    Redmond, D. Eugene, Jr.
    MOLECULAR THERAPY, 2010, 18 (03) : 588 - 593
  • [32] Novel AAV Variants Isolated by Directed Evolution in Primate Display Enhanced Retinal Transduction Following Intravitreal Injection
    Boye, Sanford L.
    Choudhury, Shreyasi
    Marsic, Damien
    Strang, Christianne
    Peterson, James J.
    Fajardo, Diego
    Bennett, Antonette
    Agbandje-McKenna, Mavis
    Witherspoon, C. Douglas
    Gamlin, Paul D.
    Zolotukhin, Sergei
    Boye, Shannon E.
    MOLECULAR THERAPY, 2017, 25 (05) : 231 - 232
  • [33] Extensive Transduction and Enhanced Spread of a Modified AAV2 Capsid in the Non-human Primate CNS
    Naidoo, Jerusha
    Stanek, Lisa M.
    Ohno, Kousaku
    Trewman, Savanah
    Samaranch, Lluis
    Hadaczek, Piotr
    O'Riordan, Catherine
    Sullivan, Jennifer
    Sebastian, Waldy San
    Bringas, John R.
    Snieckus, Christopher
    Mahmoodi, Amin
    Mahmoodi, Amir
    Forsayeth, John
    Bankiewicz, Krystof S.
    Shihabuddin, Lamya S.
    MOLECULAR THERAPY, 2018, 26 (10) : 2418 - 2430
  • [34] Efficient Retinal Transduction by AAV Variants Identified via Directed Evolution and Screening in Non-Human Primate
    Boye, Shannon E.
    Choudhury, Shreyasi
    Marsic, Damien
    Kondratov, Oleksandr
    Potter, Mark
    Peterson, James
    Calabro, Kaitlyn
    Strang, Christianne
    Zolotukhin, Sergei
    Gamlin, Paul
    Boye, Sanford
    MOLECULAR THERAPY, 2020, 28 (04) : 257 - 258
  • [35] Widespread Transduction and Spread of a Modified AAV2 Capsid in the Non Human Primate Central Nervous System
    Naidoo, Jerusha
    Stanek, Lisa
    Ohno, Kouskau
    Trewman, Savannah
    Samaranch, Lluis
    Hadaczek, Piotr
    O'Riordan, Catherine
    Sullivan, Jennifer
    Bringas, John
    Snieckus, Christopher
    Mahmoodi, Amin
    Mahmoodi, Amir
    Forsayeth, John
    Bankiewicz, Krystof
    Shihabuddin, Lamya
    MOLECULAR THERAPY, 2018, 26 (05) : 150 - 150
  • [36] Transduction of Neural Cells in Primate Brain Using Adeno-Associated Virus (AAV) Serotypes 2 and 5
    Markakis, Eleni A.
    Leranth, Csaba
    Bober, Jeremy
    Samulski, R. Jude
    Rabinowitz, J. E.
    Zhou, X.
    Vives, Kenneth
    Redmond, D. Eugene, Jr.
    MOLECULAR THERAPY, 2006, 13 : S46 - S47
  • [37] CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain
    Mathiesen, Sophie N.
    Lock, Jasmine L.
    Schoderboeck, Lucia
    Abraham, Wickliffe C.
    Hughes, Stephanie M.
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2020, 19 : 447 - 458
  • [38] Medium-Throughput Characterization of Engineered AAV Transduction Properties in NHP Retina
    Sengel, Cem
    Shanehsazzadeh, Amir
    Wec, Anna
    Reardon, Chris
    Locane, Elina
    Lykken, Erik
    Damani, Farhan
    Levitin, Hanna Mendes
    Turunen, Heikki
    Kuchwara, Helene
    Chen, Ina
    Yu, Jennifer
    Lin, Kathy
    Wheelock, Lauren
    Nagabhushana, Nishith
    McDonel, Patrick
    Badkundri, Rohil
    Wolock, Sam
    Abesteh, Shireen
    Malina, Stephen
    Lapan, Sylvain
    MOLECULAR THERAPY, 2022, 30 (04) : 441 - 441
  • [39] Chemical engineering of AAV capsids improves their biodistribution and transduction properties in neural tissues
    Lefevre, G. M.
    Burlot, M. A.
    Brument, N.
    Jordi, E.
    Gougerot, A.
    Blaettler, T.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A30 - A30
  • [40] mRNA Therapeutic Vaccine for Hepatitis B Demonstrates Immunogenicity and Efficacy in the AAV-HBV Mouse Model
    De Pooter, Dorien
    Pierson, Wim
    Pourshahian, Soheil
    Dockx, Koen
    De Clerck, Ben
    Najera, Isabel
    Davis, Heather
    Van Gulck, Ellen
    Boden, Daniel
    VACCINES, 2024, 12 (03)
12345