Spinal Cord Injury-Induced Osteoporosis: Pathogenesis and Emerging Therapies

被引：98

作者：

Battaglino, Ricardo A. ^{[1
,2
]}

Lazzari, Antonio A. ^{[3
,4
,5
]}

Garshick, Eric ^{[6
,7
]}

Morse, Leslie R. ^{[1
,8
,9
]}

机构：

[1] Forsyth Inst, Cambridge, MA 02142 USA

[2] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA

[3] VA Boston Healthcare Syst, Primary Care Sect, Boston, MA 02130 USA

[4] VA Boston Healthcare Syst, Rheumatol Sect, Boston, MA 02130 USA

[5] Boston Univ, Sch Med, Boston, MA 02130 USA

[6] VA Boston Healthcare Syst, Pulm & Crit Care Med Sect, Med Serv, West Roxbury, MA 02132 USA

[7] Harvard Univ, Sch Med, Dept Med, Channing Lab,Brigham & Womens Hosp, Boston, MA USA

[8] Spaulding Harvard SCI Model Syst, Spaulding Rehabil Hosp, Boston, MA 02114 USA

[9] Harvard Univ, Sch Med, Dept Phys Med & Rehabil, Boston, MA USA

来源：

CURRENT OSTEOPOROSIS REPORTS | 2012年 / 10卷 / 04期

关键词：

Osteoporosis; Sclerostin; Bone mineral density; Spinal cord injury; Mechanical unloading;

D O I：

10.1007/s11914-012-0117-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Spinal cord injury causes rapid, severe osteoporosis with increased fracture risk. Mechanical unloading after paralysis results in increased osteocyte expression of sclerostin, suppressed bone formation, and indirect stimulation of bone resorption. At this time, there are no clinical guidelines to prevent bone loss after SCI, and fractures are common. More research is required to define the pathophysiology and epidemiology of SCI-induced osteoporosis. This review summarizes emerging therapeutics including anti-sclerostin antibodies, mechanical loading of the lower extremity with electrical stimulation, and mechanical stimulation via vibration therapy.

引用

页码：278 / 285

页数：8

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