Magnetic Resonance Imaging-Guided Adaptive Radiation Therapy: A "Game Changer" for Prostate Treatment?

被引:136
|
作者
Pathmanathan, Angela U. [1 ,2 ]
van As, Nicholas J. [1 ,2 ]
Kerkmeijer, Linda G. W. [3 ]
Christodouleas, John [4 ]
Lawton, Colleen A. F. [5 ]
Vesprini, Danny [6 ]
van der Heide, Uulke A. [7 ]
Frank, Steven J. [8 ]
Nill, Simeon [1 ,2 ]
Oelfke, Uwe [1 ,2 ]
van Herk, Marcel [9 ,10 ]
Li, X. Allen [5 ]
Mittauer, Kathryn [11 ]
Ritter, Mark [11 ]
Choudhury, Ananya [9 ,10 ]
Tree, Alison C. [1 ,2 ]
机构
[1] Inst Canc Res, London, England
[2] Royal Marsden Natl Hlth Serv Fdn Trust, London, England
[3] Univ Med Ctr Utrecht, Utrecht, Netherlands
[4] Elekta Inc, Philadelphia, PA USA
[5] Med Coll Wisconsin, Milwaukee, WI 53226 USA
[6] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
[7] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands
[8] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
[9] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester Canc Res Ctr, Christie Natl Hlth Serv Fdn Trust, Manchester, Lancs, England
[10] Cent Manchester Univ Hosp Natl Hlth Serv Fdn Trus, Manchester Acad Hlth Sci Ctr, Manchester Biomed Res Ctr, Natl Inst Hlth Res, Manchester, Lancs, England
[11] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA
关键词
DOSE-RATE BRACHYTHERAPY; INTENSITY-MODULATED RADIOTHERAPY; INTERFRACTIONAL ANATOMIC CHANGES; RANDOMIZED CONTROLLED-TRIAL; EXTERNAL-BEAM BOOST; FILTER-FREE BEAMS; COMPUTED-TOMOGRAPHY; MR-IMAGES; AUTOMATIC SEGMENTATION; ATTENUATION-CORRECTION;
D O I
10.1016/j.ijrobp.2017.10.020
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation therapy to the prostate involves increasingly sophisticated delivery techniques and changing fractionation schedules. With a low estimated alpha/beta ratio, a larger dose per fraction would be beneficial, with moderate fractionation schedules rapidly becoming a standard of care. The integration of a magnetic resonance imaging (MRI) scanner and linear accelerator allows for accurate soft tissue tracking with the capacity to replan for the anatomy of the day. Extreme hypofractionation schedules become a possibility using the potentially automated steps of autosegmentation, MRI-only workflow, and real-time adaptive planning. The present report reviews the steps involved in hypofractionated adaptive MRI-guided prostate radiation therapy and addresses the challenges for implementation. (C) 2017 The Authors. Published by Elsevier Inc.
引用
收藏
页码:361 / 373
页数:13
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