Targeting Estrogen Receptor-β for the Prevention of Nonmelanoma Skin Cancer

被引：6

作者：

Yao, Pei-Li ^{[1
,2
]}

Gonzalez, Frank J. ^{[3
]}

Peters, Jeffrey M. ^{[1
,2
]}

机构：

[1] Penn State Univ, Dept Vet & Biomed Sci, University Pk, PA 16802 USA

[2] Penn State Univ, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA

[3] NCI, Lab Metab, Bethesda, MD 20892 USA

来源：

CANCER PREVENTION RESEARCH | 2014年 / 7卷 / 02期

关键词：

EXPRESSION; SEQUENCE; AGONIST; DESIGN; MODELS;

D O I：

10.1158/1940-6207.CAPR-13-0409

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The potential for targeting estrogen receptor (ER)-beta in various cancer models has been gaining considerable attention in recent years. In this issue of the journal, Chaudhary and colleagues demonstrate markedly decreased ultraviolet B (UVB)-induced skin cancer in a mouse model using a highly specific ER-beta agonist, ERB-041. The mechanisms that underlie this strong inhibitory effect are mediated by inhibition of proinflammatory signaling and epithelial-mesenchymal transition (EMT). The changes in EMT were due in part to modulation of WNT/beta-catenin signaling. Collectively, the results from these studies provide important new insights into the mechanisms by which the ER-beta agonist ERB-041 inhibits UVB-induced skin cancer and opens the door for future studies that could examine combinatorial approaches for UVB-dependent skin cancer chemoprevention. (C) 2014 AACR.

引用

页码：182 / 185

页数：4

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