Targeting regulatory T cells in vaccination: In silico identified small molecule CCR4 antagonists exert adjuvant activity

被引:0
|
作者
Bayr, Jagadeesh [1 ,2 ]
Tchilian, Elma Z. [3 ]
Davies, Matthew N. [2 ]
Beverley, Peter C. L. [2 ,3 ]
Flower, Darren R. [2 ]
Tough, David F. [2 ,4 ]
机构
[1] INSERM, U872, Ctr Rech Cordeliers, Paris, France
[2] Univ Oxford, Edward Jenner Inst Vaccine Res, Compton, England
[3] Univ Oxford, Oxford, England
[4] GlaxoSmithKline, Stevenage, Herts, England
来源
JOURNAL OF IMMUNOLOGY | 2009年 / 182卷
关键词
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
96.12
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells
    Powell, Jonathan
    Mota, Filipa
    Steadman, David
    Soudy, Christelle
    Miyauchi, Jeremy T.
    Crosby, Stuart
    Jarvis, Ashley
    Reisinger, Tifelle
    Winfield, Natalie
    Evans, Graham
    Finniear, Aled
    Yelland, Tamas
    Chou, Yi-Tai
    Chan, A. W. Edith
    O'Leary, Andrew
    Cheng, Lili
    Liu, Dan
    Fotinou, Constantina
    Milagre, Carla
    Martin, John F.
    Jin, Haiyan
    Franke, Paul
    Djordjevic, Snezana
    Tsirka, Stella E.
    Zachary, Ian C.
    Selwood, David L.
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (09) : 4135 - 4154
  • [42] Purpuric adult T-cell leukaemia/lymphoma: expansion of unusual CD4/CD8 double-negative malignant T cells expressing CCR4 but bearing the cytotoxic molecule granzyme B
    Shimauchi, T
    Hirokawa, Y
    Tokura, Y
    BRITISH JOURNAL OF DERMATOLOGY, 2005, 152 (02) : 350 - 352
  • [43] Recruitment of Human Regulatory T-Cells to Porcine Endothelium Is Mediated by CXCR3 and CCR4 Chemokine Receptors and CD18 and CD49d Integrins
    Ehirchiou, D.
    Chicheportiche, R.
    Nobari, R. Heyrani
    Muller, Y. D.
    Schneider, M. K. J.
    Seebach, J. D.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2011, 11 : 526 - 526
  • [44] Tob, a novel Tob/BTG1 family member that associates with the CCR4 transcriptional regulatory couples is selectively expressed in anergic T cells and inhibits IL-2 transcription.
    Tzachanis, D
    Hirano, N
    Freeman, GJ
    Nadler, LM
    Boussiotis, VA
    BLOOD, 2000, 96 (11) : 810A - 810A
  • [45] Targeting tumor-infiltrating CCR8+ regulatory T cells induces antitumor immunity through functional restoration of CD4+ Tconvs and CD8+ T cells in colorectal cancer
    Chen, Qian
    Shen, Meiying
    Yan, Min
    Han, Xiaojian
    Mu, Song
    Li, Ya
    Li, Luo
    Wang, Yingming
    Li, Shenglong
    Li, Tingting
    Wang, Yingying
    Wang, Wang
    Wei, Zhengqiang
    Hu, Chao
    Jin, Aishun
    JOURNAL OF TRANSLATIONAL MEDICINE, 2024, 22 (01)
  • [46] Suppression of regulatory T cells (Tregs) in vivo by small molecule targeting of the mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)
    Finnberg, N.
    Oberg, F.
    Mangsbo, S.
    Kerzeli, I.
    Fletcher, E.
    Kallin, A.
    Christodoulidou, A.
    Sedig, S.
    Sternbeck, A. K.
    Bylund, J.
    Moses, S.
    Oden, L. Salvador
    Kullman-Magnusson, M.
    Henderson, I.
    Beisel, H. G.
    Ersmark, K.
    Karlstrom, S.
    Bethell, R.
    Albertella, M.
    EUROPEAN JOURNAL OF CANCER, 2018, 103 : E74 - E74
  • [47] Targeting the Negative Immune Regulatory Molecule B7-H4 on Both Tumor and Normal Tissue With Anti-B7-H4 CAR T Cells
    Smith, Jenessa B.
    Lanitis, Evripidis
    Dangaj, Denarda
    Poussin, Mathilde
    McLane, Michael
    Scholler, Nathalie
    Powell, Daniel J.
    MOLECULAR THERAPY, 2015, 23 : S206 - S206
  • [48] CD4+CD25+Foxp3+T Regulatory Cells, Th1 (CCR5, IL-2, IFN-G) and Th2 (CCR4, IL-4, IL-13) Type Chemokine Receptors and Intracellular Cytokines in Children with Common Variable Immunodeficiency
    Kutukculer, N.
    Karaca, N. E.
    Azarsiz, E.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2014, 34 : S457 - S457
  • [49] CD4+CD25+Foxp3+ T regulatory cells, Th1 (CCR5, IL-2, IFN-γ) and Th2 (CCR4, IL-4, IL-13) type chemokine receptors and intracellular cytokines in children with common variable immunodeficiency
    Kutukculer, Necil
    Azarsiz, Elif
    Aksu, Guzide
    Karaca, Neslihan Edeer
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 2016, 29 (02) : 241 - 251
  • [50] Effects of Small-Molecule Inhibitors of TNFR2 Signaling Pathways On TNF-Mediated Expansion of CD4+FoxP3+Regulatory T Cells
    Wu, Xueqiang
    Chen, Yan
    Han, Chunsheng
    Gong, Yiwen
    Bu, Dingfang
    Zhang, Yin
    Xia, Junyan
    Liu, Qian
    Chen, Xue
    Hu, Yang
    Zhu, Ping
    BLOOD, 2012, 120 (21)