Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

被引：60
|
作者：
Du, Zhenting [1 ,2 ]
Si, Changmei [1 ]
Li, Youqiang [1 ]
Wang, Yin [1 ]
Lu, Jing [1 ]
机构：
[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China
[2] Talimu Univ, Key Lab Protect & Utilizat Biol Resources Tarim B, Alaer 843300, Xinjiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 04期
关键词：
silica sulfuric acid; 5-substituted; 1H-tetrazoles; 3+2] cycloaddition; REUSABLE HETEROGENEOUS CATALYST; PHENYL-TETRAZOLYL ACETOPHENONES; STEREOSELECTIVE-SYNTHESIS; ALLOSTERIC POTENTIATORS; TRIMETHYLSILYL AZIDE; EFFICIENT; DISCOVERY; RECEPTOR;
D O I：
10.3390/ijms13044696
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.
引用
收藏
页码：4696 / 4703
页数：8
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