Improved Synthesis of 5-Substituted 1H-Tetrazoles via the [3+2] Cycloaddition of Nitriles and Sodium Azide Catalyzed by Silica Sulfuric Acid

被引：60

作者：

Du, Zhenting ^{[1
,2
]}

Si, Changmei ^{[1
]}

Li, Youqiang ^{[1
]}

Wang, Yin ^{[1
]}

Lu, Jing ^{[1
]}

机构：

[1] NW A&F Univ, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] Talimu Univ, Key Lab Protect & Utilizat Biol Resources Tarim B, Alaer 843300, Xinjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 04期

关键词：

silica sulfuric acid; 5-substituted; 1H-tetrazoles; 3+2] cycloaddition; REUSABLE HETEROGENEOUS CATALYST; PHENYL-TETRAZOLYL ACETOPHENONES; STEREOSELECTIVE-SYNTHESIS; ALLOSTERIC POTENTIATORS; TRIMETHYLSILYL AZIDE; EFFICIENT; DISCOVERY; RECEPTOR;

D O I：

10.3390/ijms13044696

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A silica supported sulfuric acid catalyzed [3+2] cycloaddition of nitriles and sodium azide to form 5-substituted 1H-tetrazoles is described. The protocol can provide a series of 5-substituted 1H-tetrazoles using silica sulfuric acid from nitriles and sodium azide in DMF in 72%-95% yield.

引用

页码：4696 / 4703

页数：8

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