Progression of cerebral white matter abnormalities in early treated patients with phenylketonuria during adolescence

被引：11
|
作者：
Weglage, J
Bick, U
Schuierer, G
Pietsch, M
Sprinz, A
Zass, R
Ullrich, K
机构：
[1] UNIV MUNSTER,DEPT RADIOL,D-48129 MUNSTER,GERMANY
[2] UNIV HAMBURG,DEPT PEDIAT,HAMBURG,GERMANY
来源：
NEUROPEDIATRICS | 1997年 / 28卷 / 04期
关键词：
phenylketonuria; cranial MRI;
D O I：
10.1055/s-2007-973707
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In this study of cranial MRI a group of 15 adolescents with classical phenylketonuria and permanent blood phenylalanine (phe) checks from infancy was investigated twice with an interval of three years in between. Cranial MRI revealed a progression of white matter abnormalities in patients with moderate and poor control of blood phe levels, however not in well controlled patients. Nevertheless results indicate an individual vulnerability of the brain against elevated phenylalanine levels in phenylketonurics.
引用
收藏
页码：239 / 240
页数：2
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