The Complex Function of Hsp70 in Metastatic Cancer

被引：71

作者：

Juhasz, Kata ^{[1
]}

Lipp, Anna-Maria ^{[1
]}

Nimmervoll, Benedikt ^{[1
]}

Sonnleitner, Alois ^{[1
]}

Hesse, Jan ^{[1
]}

Haselgruebler, Thomas ^{[1
]}

Balogi, Zsolt ^{[1
]}

机构：

[1] Ctr Adv Bioanalysis GmbH, Gruberstr 40-42, A-4020 Linz, Austria

来源：

CANCERS | 2014年 / 6卷 / 01期

关键词：

Hsp70; metastasis; invasion; trafficking; lysosome; HEAT-SHOCK-PROTEIN; HEAT-SHOCK-PROTEIN-70 PEPTIDE COMPLEXES; EPITHELIAL-MESENCHYMAL TRANSITION; SEVERE COMBINED IMMUNODEFICIENCY; CELL-SURFACE EXPRESSION; NATURAL-KILLER-CELLS; TUMOR-CELLS; EXTRACELLULAR HSP70; CARCINOMA-CELLS; MOLECULAR CHAPERONES;

D O I：

10.3390/cancers6010042

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Elevated expression of the inducible heat shock protein 70 ( Hsp70) is known to correlate with poor prognosis in many cancers. Hsp70 confers survival advantage as well as resistance to chemotherapeutic agents, and promotes tumor cell invasion. At the same time, tumor-derived extracellular Hsp70 has been recognized as a "chaperokine", activating antitumor immunity. In this review we discuss localization dependent functions of Hsp70 in the context of invasive cancer. Understanding the molecular principles of metastasis formation steps, as well as interactions of the tumor cells with the microenvironment and the immune system is essential for fighting metastatic cancer. Although Hsp70 has been implicated in different steps of the metastatic process, the exact mechanisms of its action remain to be explored. Known and potential functions of Hsp70 in controlling or modulating of invasion and metastasis are discussed.

引用

页码：42 / 66

页数：25

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