Furan oligomers and β-carbolines from terrestrial streptomycetes

被引：37
|
作者：
Fotso, Serge [1 ]
Maskey, Rajendra P. [1 ]
Schroeder, Dirk [1 ]
Ferrer, Anna S. [1 ]
Gruen-Wollny, Iris [2 ]
Laatsch, Hartmut [1 ]
机构：
[1] Univ Gottingen, Dept Organ & Biomol Chem, D-37077 Gottingen, Germany
[2] Lab Grun Wollny, D-35394 Giessen, Germany
来源：
JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 09期
关键词：
D O I：
10.1021/np800248s
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
2,5-Bis(hydroxymethyl)furan monoacetate (3) and 2,5 -bis(hydroxymethyl)furan diacetate (4) were obtained as new natural products from an ethyl acetate extract of the terrestrial Streptomyces sp. isolate GW11/1695. Another Streptomyces isolate. GW21/1313, delivered a dimer (6) and a trimer (7) of (hydroxymethyl)furfural. The latter strain also produced 4-hydroxy-2-(5 -(hydroxymethyl)furan-2-ylmethylene)-5-methylfuran-3-one (5), perlolyrin (8), and two new beta-carboline derivatives, 9 and 10. 2,5-Bis(hydroxymethyl)furan diacetate (4) exhibited weak cytotoxic activity against brine shrimp larvae.
引用
收藏
页码：1630 / 1633
页数：4
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