Effect of type I collagen piezoelectricity on cellular adhesion

Bone healing and growth are controlled by the rate of deposition of hydroxyapatite (HA). This process have been so far accredited to the work of osteoblasts, which are attracted by the electrical dipoles produced either by piezoelectricity, due to deformation of the bone, specially the collagen in it, or due to outside electrical stimuli. The main purpose of this work was to study the influence of the cortical bone collagen piezoelectricity effect, on the osteoblastic cells orientation. To evaluate the cellular adhesion on the cortical bone collagen subject to deformation, bone cells of newborn calvaria's rats were extracted. The bone collagen was prepared and deformed following the specifications described in earlier studies. The results of this study shown that the piezoelectric phenomena of bone collagen promotes the cell's adhesion on the compression side more than tension side compared with undeformed surface. Further studies ascertaining the osteoblastic activity due to the electric field are being advanced.