Cytotoxicity of estradiol, equilin equilenin and their derivatives on Chinese hamster V79 cells

被引：2
|
作者：
Oda, T [1 ]
Ikeda, N [1 ]
Nakashima, S [1 ]
Sato, Y [1 ]
机构：
[1] Kyoritsu Coll Pharmaceut Sci, Minato Ku, Tokyo 1058512, Japan
来源：
DRUG AND CHEMICAL TOXICOLOGY | 2002年 / 25卷 / 01期
关键词：
D O I：
10.1081/DCT-100108473
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Recently, we investigated the inhibitory effects of 17beta-estradiol and diethylstilbestrol on microtubule assembly, cytotoxicity, and aneuploidy in V79 cells. The present study analyzes the effects of equilin and equilenin (amongst the natural estrogens originally isolated from the urine of pregnant horses) and their related compounds, on the relative plating efficiency of Chinese hamster V79 cells. The results showed that a hydroxyl group on 17-C and a methoxyl group on 3-C of the estrogen skeleton were important for cytotoxicity. Of the various compounds analyzed, 2-methoxyestradiol had the strongest cytotoxicity, suggesting also the importance of a methoxyl group on 2-C.
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页码：75 / 82
页数：8
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