A convenient synthesis of highly substituted 2-pyridones

被引：23
|
作者：
Collins, I [1 ]
Castro, JL [1 ]
机构：
[1] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Res Lab, Dept Med Chem, Harlow CM20 2QR, Essex, England
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期
关键词：
pyridones; coupling reactions; Vilsmeier reactions reagents;
D O I：
10.1016/S0040-4039(99)00651-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A rapid and convenient synthesis of the 3-trifluoromethanesulfonyloxy-2-pyridone 2, one of the first examples of this class of compound, was achieved by Vilsmeier formylation and cyclisation of the acyl enamine 6. The triflate 2 was found to undergo a range of palladium-catalysed coupling reactions giving a synthetic sequence of general use for the preparation of highly substituted 2-pyridones. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：4069 / 4072
页数：4
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